DevOps with AWS is a methodology that combines development and operations practices using Amazon Web Services to enhance collaboration and efficiency in software development and deployment. It focuses on automating and streamlining the software lifecycle through Infrastructure as Code (IaC) with services like AWS CloudFormation and AWS CDK, Continuous Integration/Continuous Deployment (CI/CD) using AWS CodePipeline, CodeBuild, and CodeDeploy, as well as monitoring and logging with Amazon CloudWatch and AWS X-Ray. Additionally, it supports containerization with Amazon ECS and EKS, and serverless architectures using AWS Lambda. This approach promotes scalability, cost efficiency, speed, reliability, and fosters a culture of continuous improvement in software delivery.